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HIV controllers: state of the art

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HIV controllers are rare chronically HIV-1-infected patients in whom viral replication is undetectable in the absence of antiretroviral treatment. Most such patients are nonetheless infected by replication-competent viruses. An effective multifunctional HIV-specific CD8+ T cell response and functional CD4 T cells are thought to be central to viral control in these individuals. The mechanisms underlying this spontaneous control of HIV infection are the focus of intensive investigations, as they should help to unravel the pathogenesis of AIDS and to provide new clues for the design of effective vaccine strategies. In this review we examine recent findings from these studies.

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Correspondence to Olivier Lambotte.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Infectious Disease
  • Cancer Research
  • Cell Response
  • Viral Replication
  • Effective Vaccine