Polymorphisms of HIV-2 integrase and selection of resistance to raltegravir

Retrovirology

Table 2 IN variability and polymorphism frequencies in treatment-naïve and treatment-experienced HIV-2 infected patients

	Gene	mutated positions	p	Positions with ≥ 2 mutations	p
All patients	IN	97/293 (33.1%)		61/293 (19.8%)
	PR	46/101 (45.5%)	0.030	33/101 (32.6%)	0.022
	RT	173/439 (39.4%)	0.086	118/439 (26.8%)	0.080
Treatment-naïve	IN	94/293 (32.1%)		58/293 (19.8%)
	PR	37/101 (36.6%)	0.323	21/101(20.8%)	0.885
	RT	155/439 (35.3%)	0.202	96/439 (20.9%)	0.518
Treatment-experienced	IN	63/293 (21.5%)		42/293 (14.3%)
	PR	35/101 (34.6%)	0.006	23/101(22.7%)	0.061
	RT	112/439 (25.5%)	0.13	65/439 (14.8%)	0.915

Variable and polymorphic position frequencies in IN with respect to RT and to PR were compared in treatment-naïve and treatment-experienced patients. Variable positions and positions supporting variability at least twice are reported. Polymorphism frequency was compared using a Fisher exact test, and considered statistically different when p < 0.05.

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