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Table 1 Env sequence characteristics of amino acid length and potential N-linked glycosylation sites for slow progressors and progressors#

From: HIV-1 subtype C envelope characteristics associated with divergent rates of chronic disease progression

Patient

V1V2

C2V3

C3V4

C4V5

gp41

 

mean length (range)

mean PNGs

(range)

mean length

(range)

mean PNGs

(range)

mean length (range)

mean PNGs (range)

mean length (range)

mean PNGs (range)

mean length (range)

mean PNGs (range)

Slow progressors

          

SK035 entry

69 (62-72)

6 (3-7)

133

8

80 (75-81)

7 (5-8)

53 (52-56)

3 (3-4)

252

5 (3-5)

SK035 exit

69 (59-70)

6 (4-8)

133

8

82 (80-88)

7 (6-8)

53 (52-58)

3 (2-4)

250(243-252)

5 (4-5)

SK036 entry

64 (61-73)

5 (4-6)

133

6 (7-8)

84 (82-84)

8 (8-9)

52

3 (2-3)

243(243)

4 (3-5)

SK036 exit

66 (59-73)

4 (3-6)

133

8 (7-8)

84

8 (7-9)

52

3 (2-3)

243(243)

5 (4-5)

SK169 entry

75 (71-80)

6 (5-7)

133(132-133)

6 (6-8)

85 (84-88)

7 (6-8)

54 (52-55)

3 (2-4)

245(241-245)

3 (3-4)

SK169 exit

76 (71-77)

7 (6-7)

133

6 (6-8)

86 (84-95)

7 (4-10)

54 (51-55)

3 (2-4)

245(245)

3 (3-4)

SK312 entry

66 (60-69)

5(3-5)

133

6

90 (85-97)

9 (5-11)

51 (50-54)

3 (2-4)

239(233-252)

3

SK312 exit

67 (67-69)

5

133

6

90 (84-97)

8 (4-10)

51 (50-55)

3 (1-4)

239(236-252)

3

Mean (range) over time

69 (64-75)

6 (4-7)

133

7 (6-8)

85 (81-90)

8 (7-9)

53 (51-54)

3

245(239-252)

4 (3-5)

Progressors

          

SK010 entry

65

6

133

8

79 (77-82)

8 (7-9)

52 (52-53)

3

252

3

SK010 exit

65 (65-66)

6

133

8

78 (75-79)

7 (5-8)

52 (50-54)

3

252

3

SK200 entry

66 (64-78)

6 (6-7)

133

8

76 (75-76)

6 (6-7)

52

2 (2-3)

252

3 (2-3)

SK200 exit

73 (71-73)

6 (6-8)

133

8

76 (75-76)

7

52

3

252

3 (2-3)

SK221 entry

72 (55-74)

7 (3-8)

133

9

77 (73-82)

7 (7-8)

51

3 (3-4)

252

2

SK221 exit

71 (63-76)

5 (4-5)

133

9

85 (74-90)

8 (6-9)

51

3 (3-4)

246(245-252)

2

SK233 entry

58

4

133

8

84 (84)

9 (8-9)

52 (50-51)

3

245

3 (3-4)

SK233 exit

59 (59-63)

5 (5-6)

133

8 (7-8)

84 (84)

9 (8-9)

53 (52-53)

3 (2-4)

245

3 (3-4)

Mean (range) over time

66 (59-72)

6 (4-7)

133

8 (8-9)

82 (76-88)

8 (7-9)

52 (51-53)

3 (2-4)

250(245-252)

3 (2-3)

p Value

p = 0.32

p = 0.78

NS

*p = 0.009

p = 0.02

p = 0.96

p = 0.29

p = 0.15

p = 0.02

p = 0.02

  1. p value was calculated using the two-tailed Mann-Whitney non-parametric test overall between the slow progressors and progressors.
  2. Where only the mean is reflected it is because it is equivalent to the range.
  3. * represents the p value that remained significant after Bonferroni adjustment for multiple comparisons (p < 0.01), NS represents a non-significant p value. Potential N-linked glycosylation = PNGs.
  4. # Data for V1-V4 length is as follows: slow progressors had a mean of 286 amino acids (range 282-294) versus progressors' 281 amino acids (range 276-292; p = 0.009).
  5. # Data for V1-V4 PNGs is as follows: slow progressors had a mean of 20 PNGS (range 19-21) versus a mean of 22 PNGs (range 20-23) in progressors (p = 0.02).
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Retrovirology

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