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Table 1 Comparison of NNRTI efficacies in various assay systems

From: Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease

  Inhibition of HIV replication in vitroEC50[nM] Enhancement of Gag processing (Fig. 2) Cytotoxicity on MT4-CMV-EGFP control cells CC50[μM] Cytotoxicity on MT4-LTR-EGFP-IIIB HIV-1 producing cells CC50[μM] Ctotoxicity on MT4-LTR-EGFP-IIIB cells in presence of 0.1 μM DRV CC50[μM] Enhancement of RT-Dimerization EC50[μM]
IDX-12899 1.9 ± 1.3 ++ > 10 0.29 ± 0.21 > 10 0.0046
GW-678248 0.84 ± 0.25 ++ > 10 0.63 ± 0.29 > 10 0.0032
VRX-480773 1.6 ± 0.81 ++ 5.82 ± 1.44 0.68 ± 0.34 6.33 ± 0.08 0.0040
EFV 1.9 ± 0.9 + > 10 1.71 ± 0.43 > 10 0.020
ETV 3.2 ± 5 + > 10 > 10 > 10 0.27
UK-453061 7.5 ± 1.4 - > 10 > 10 > 10 0.15
NVP 42 ± 20 - > 10 > 10 >10 18
TMC-120 1.7 ± 1.4 - 3.02 ± 0.90 2.56 ± 0.74 4.33 ± 0.81 ND
  1. *mean values and standard deviations from three or more independent measurements are shown; ND, not done.