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Table 3 Parameter descriptions

From: In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy

Parameters Definition Values
N Number of shRNA transduced into HSC 2, 4, or 6
P Proportion of transduced HSC 1%, 20%
Time - step Time-step of each iteration 12 hours
eff Efficacy of each shRNA inhibiting viral production and/or infection, dependent on resistance mutations. Inhibition per shRNA was (1-eff). 0.8, 0.5, 0
fitness Fitness of viral strain relative to wild type 0.5, 0.9, 0.99
lifespan Lifespan of newly infected cell. Determined from Poisson distribution. Cells with a lifespan of 0 are considered long-lived. Mean value of 4 time-steps.
P.neigh Probability a dead cell is replaced by an uninfected neighbour, provided one exists. Alternatively it is replaced by a new cell generated from HSC. 0.99
P.mut Probability of mutation per nt per reverse transcription 3.4 × 10-5
P.inf Probability of infection relative to total neighbouring viral production and cell transduction 0.0667