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Table 1 RT inhibitor susceptibilities for HIV-1 subtype B and subtype C recombinant RTs

From: Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C

RT inhibitors

IC50(μM)a

 

B RT-1b

B RT-2c

C RT-1 d

C RT-2 e

ZDV-TP

3.1 ± 0.5

2.9 ± 0.4

4.3 ± 0.4

3.8 ± 0.5

3TC-TP

2.7 ± 0.3

4.2 ± 0.5

3.7 ± 0.6

4.1 ± 0.4

TFV-DP

2.5 ± 0.3

2.1 ± 0.3

2.6 ± 0.5

2.9 ± 0.4

NVP

3.2 ± 0.4

5.3 ± 1.4

3.3 ± 0.4

4.3 ± 0.3

EFV

0.11 ± 0.03

0.22 ± 0.03

0.20 ± 0.02

0.18 ± 0.02

ETR

0.17 ± 0.03

0.16 ± 0.02

0.15 ± 0.04

0.19 ± 0.03

  1. a Data represent means ± standard deviations of three determinations.
  2. b NL4-3
  3. c HXB2
  4. d Isolate BG05 (GenBank accession number AF492609)
  5. e Isolate M01 (GenBank accession number AF492603)
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Retrovirology

ISSN: 1742-4690

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