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Table 1 RT inhibitor susceptibilities for HIV-1 subtype B and subtype C recombinant RTs

From: Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C

RT inhibitors IC50(μM)a
  B RT-1b B RT-2c C RT-1 d C RT-2 e
ZDV-TP 3.1 ± 0.5 2.9 ± 0.4 4.3 ± 0.4 3.8 ± 0.5
3TC-TP 2.7 ± 0.3 4.2 ± 0.5 3.7 ± 0.6 4.1 ± 0.4
TFV-DP 2.5 ± 0.3 2.1 ± 0.3 2.6 ± 0.5 2.9 ± 0.4
NVP 3.2 ± 0.4 5.3 ± 1.4 3.3 ± 0.4 4.3 ± 0.3
EFV 0.11 ± 0.03 0.22 ± 0.03 0.20 ± 0.02 0.18 ± 0.02
ETR 0.17 ± 0.03 0.16 ± 0.02 0.15 ± 0.04 0.19 ± 0.03
  1. a Data represent means ± standard deviations of three determinations.
  2. b NL4-3
  3. c HXB2
  4. d Isolate BG05 (GenBank accession number AF492609)
  5. e Isolate M01 (GenBank accession number AF492603)