Figure 3

Viral dynamics in SIV-infected macaques receiving a short-term HAART before the viremia peak. Seven days after SIV infection, 4 macaques received either a placebo (placebo d21: open symbol) or the AZT/3TC/IDV combination (HAART d7-d21: black symbol) for 14 days and were killed at the end of treatment (21 days pi). Initiation of HAART 7 days after SIV infection conducts to a significant decrease of PVL (a) but non-significant reduction of CVL (b). Viral dissemination is also slightly (but significantly) impacted in almost all tissues (c), whereas viral replication is only reduced in the spleen, peripheral LN and colon (d, e). Due to its controller profile, placebo animal #14275 was excluded from statistical analysis. *: indicated a significant difference (p < 0.05) and t a trend (0.05 < p < 0.06) using a Mann-Whitney test. LN: lymph node, G mean: geometric mean. The grey area indicates the quantitative threshold of our qRT-PCR and qPCR assays.