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Table 4 Neutralization sensitivity to monoclonal antibodies, sCD4 and anti-CD4

From: Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade C envclones obtained at different time points from antiretroviral naïve Indian patients with recent infection

Envclones

b6

b12

2G12

17b

2F5

4E10

sCD4

SIM.2*

2.J8

>6.66

2.23

>6.66

>6.66

>6.66

0.34

3.66

120

2.J9

>6.66

2.16

>6.66

>6.66

>6.66

0.38

3.27

104

2-3.J4

>6.66

1.97

>6.66

>6.66

>6.66

3.36

>6.66

260

2-3.J7

>6.66

2.19

>6.66

>6.66

>6.66

5.85

>6.66

260

2-3.J17

>6.66

2.04

>6.66

>6.66

>6.66

4.85

>6.66

106

2-3.J18

>6.66

0.5

>6.66

5.1

>6.66

4.5

>6.66

37

2-5.J3

>6.66

0.29

>6.66

>6.66

>6.66

2.69

>6.66

201

2-5.J11

>6.66

0.21

>6.66

>6.66

>6.66

0.32

6.05

152

3.J16

>6.66

>6.66

4.20

>6.66

>6.66

0.23

0.54

103

3-3.J9

>6.66

>6.66

0.18

2.9

>6.66

0.3

0.1

76

3-5.J25

>6.66

>6.66

4.85

>6.66

>6.66

2.6

3.3

106

3-5.J38

>6.66

>6.66

4.30

>6.66

>6.66

2.22

>6.66

79

4.J2

>6.66

>6.66

>6.66

>6.66

>6.66

0.28

0.5

10

4.J22

>6.66

>6.66

>6.66

>6.66

>6.66

4

>6.66

138

4.J27

>6.66

>6.66

>6.66

>6.66

>6.66

5.28

>6.66

142

4-2.J41

>6.66

>6.66

>6.66

>6.66

>6.66

2.64

2.28

164

4-2.J45

>6.66

>6.66

>6.66

>6.66

>6.66

3.94

2.53

50

4-2.J42b

>6.66

>6.66

>6.66

>6.66

>6.66

5

>6.66

224

4-2.J45b

>6.66

>6.66

>6.66

>6.66

>6.66

6.2

>6.66

265

4-2.J46b

>6.66

>6.66

>6.66

>6.66

>6.66

>6.66

>6.66

240

4-2.J47b

>6.66

>6.66

>6.66

>6.66

>6.66

6.5

>6.66

212

4-5.J5

>6.66

>6.66

>6.66

>6.66

>6.66

>6.66

>6.66

334

5.J41

>6.66

>6.66

>6.66

>6.66

>6.66

0.29

0.5

114

5-3.J2

>6.66

>6.66

>6.66

>6.66

>6.66

5.6

>6.66

119

5-3.J4

>6.66

>6.66

>6.66

>6.66

>6.66

>6.66

>6.66

119

5-3.J5

5.9

>6.66

>6.66

>6.66

>6.66

5.66

>6.66

210

5-3.J9

>6.66

>6.66

>6.66

>6.66

>6.66

>6.66

>6.66

222

5-4.J16

>6.66

>6.66

>6.66

>6.66

>6.66

2.32

2.94

320

5-4.J18

>6.66

>6.66

>6.66

>6.66

>6.66

2.52

>6.66

157

5-4.J22

2.5

>6.66

>6.66

>6.66

>6.66

0.24

0.23

44

5-4.J49

5.9

>6.66

>6.66

>6.66

>6.66

0.52

0.53

121

11.J25

>6.66

>6.66

>6.66

>6.66

>6.66

0.34

3

99

11.J28

>6.66

>6.66

>6.66

>6.66

>6.66

0.32

2.4

88

11-3.J3

>6.66

>6.66

>6.66

>6.66

>6.66

5.64

>6.66

548

11-3.J9

>6.66

>6.66

>6.66

>6.66

>6.66

3.35

>6.66

555

11-3.J16

>6.66

6.05

>6.66

>6.66

>6.66

3.25

>6.66

585

11-5.J12

>6.66

>6.66

>6.66

>6.66

>6.66

2.67

>6.66

571

  1. Values are concentrations resulting 50% reduction in relative luminescence unit (RLU) as an indicator of neutralization sensitivity in TZM-bl cells following infection with pseudoviruses with 200TCID50. The IC50 values are average of two independent assays wherein each assay was done in duplicates. * The values corresponding to anti-CD4 SIM.2 is hybridoma fluid are reciprocal dilutions giving 50% reduction in relative luminescence unit (RLU).
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