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Table 2 Susceptibility of XMRV and HIV-1 to integrase inhibitors.

From: Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors

 

EC50(nM)a

Inhibitor

HIV-1NL4-3

XMRVVP62+LtatSNb

XMRV22Rv1+LtatSNb

raltegravir

3.7 ± 2.1

2.1 ± 1.1 (1)

2.2 ± 1.1 (1)

elvitegravir

1.9 ± 0.7

150 ± 115 (79)

87 ± 29 (46)

  1. a EC50 values were measured in MAGIC-5A cells as described in Methods and are the means ± standard deviation from two or more independent experiments. Numbers in parentheses indicate the fold change in EC50 relative to HIV-1NL4-3. Values shown in bold are significantly different from the corresponding values for HIV-1NL4-3 (p < 0.05, ANOVA with Tukey's multiple comparison test).
  2. b XMRV-pseudotyped LtatSN virus. See text for details.
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Retrovirology

ISSN: 1742-4690

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