Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission

Table 5 Inhibitory activity of ML-OVA on the association between sCD4 and distinct HIV envelope proteins.

Chemically modified protein	Inhibitory activity (μM)^a	The HIV envelope proteins
		gp120 of HIV-1_IIIB	gp120 of HIV-1_MN	gp120 of HIV-1_BaL	gp105 of HIV-2_ROD
ML-OVA	IC₅₀	0.471 ± 0.063	1.161 ± 0.092	1.397 ± 0.008	0.466 ± 0.076
	IC₉₀	3.258 ± 0.413	8.567 ± 2.360	19.77 ± 1.491	11.36 ± 3.721
OVA	IC₅₀	>100	>100	>100	>100
	IC₉₀	>100	>100	>100	>100

^aThe measurements were performed in triplicate, and the experiment was repeated twice. Data are presented in means ± SD.

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