Table 1 Comparison of the anti-HIV-1 activities and the percentages of modified residues of different compounds modified by 3-hydroxyphthalic anhydride.
HP-modified compounds | % modified residues |  | Inhibitory activity (μM) on a | |||
|---|---|---|---|---|---|---|
| Â | Â | Â | HIV-1IIIB | HIV-1BaL | ||
| Â | Lysine | Arginine | IC50 | IC90 | IC50 | IC90 |
HP-OVA | 99.27 ± 0.60 | 94.36 ± 1.34 | 0.006 ± 0.001 | 0.019 ± 0.005 | 0.118 ± 0.018 | 0.359 ± 0.083 |
HP-RSA | 99.00 ± 0.37 | 92.65 ± 1.23 | 0.003 ± 0.000 | 0.006 ± 0.000 | 0.297 ± 0.036 | 0.574 ± 0.058 |
HP-PSA | 98.66 ± 0.46 | 94.31 ± 1.09 | 0.005 ± 0.001 | 0.012 ± 0.004 | 0.411 ± 0.021 | 0.823 ± 0.030 |
HP-G-FS | 99.63 ± 0.08 | 1.28 ± 2.21 | 0.503 ± 0.157 | 1.268 ± 0.221 | >8.00 | >8.00 |
HP-G-PS | 99.81 ± 0.09 | 10.48 ± 1.52 | 1.182 ± 0.225 | 3.561 ± 1.314 | >8.00 | >8.00 |