Figure 2From: Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?Model for HIV-1 Vpr mechanism of action. HIV-1 Vpr recruits the Cul4A-DDB1 ubiquitin ligase through DCAF1 binding, which leads to the ubiquitination and inactivation of an unknown cellular target required for entry into mitosis.Back to article page