Figure 4

CRF02 is a recombinant derived from old and contemporary subtypes A and G. (A) Maximum Likelihood trees of consensus sub-regions delimited by breakpoints shared by most CRF02 and AG recombinant sequences. Bootstrap support values for clustering are shown. The relationship between CRF02 and subtypes A and G inferred from the ML results is defined as: CRF02 is a sibling of subtype A (As), sibling of G (Gs), parent of G (Gp), descendent of A (Ad), descendent of G (Gd), a mixture between A and G but do not cluster with either A or G (A/G). The relationships supported by ≥ 70% bootstrap values are in bold, otherwise in plain font. (B) The consensus sub-regions (I through VIII) were mapped onto the HXB2 genome. Also shown here is the RIP result for assessing CRF02's similarity to the ML-derived-ancestral and contemporary-consensus sequences of subtypes A and G.