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Table 2 Bayesian estimates of evolutionary parameters of the HIV-1 CRF12_BF and CRF38_BF epidemics.

From: Phylodynamics of HIV-1 Circulating Recombinant Forms 12_BF and 38_BF in Argentina and Uruguay

Subtype

Gene

Coalescent

Molecular clock

μ

Tmrca

CRF12_BF

pol

Bayesian Skyline

Strict

2.4 Ă— 10-3

(1.9 Ă— 10-3-2.9 Ă— 10-3)

1982

(1976-1986)

   

Relaxed

2.4 Ă— 10-3

(1.8 Ă— 10-3-3.1 Ă— 10-3)

1983

(1978-1988)

  

Logistic growth

Strict

2.4 Ă— 10-3

(1.9 Ă— 10-3-2.8 Ă— 10-3)

1982

(1978-1986)

   

Relaxed

2.5 Ă— 10-3

(1.9 Ă— 10-3-3.0 Ă— 10-3)

1983

(1979-1987)

CRF38_BF a

pol

Bayesian Skyline

Strict

1.8 Ă— 10-3

(1.5 Ă— 10-3-2.2 Ă— 10-3)

1985

(1977-1989)

   

Relaxed

1.9 Ă— 10-3

(1.5 Ă— 10-3-2.3 Ă— 10-3)

1986

(1981-1990)

  

Logistic growth

Strict

1.8 Ă— 10-3

(1.5 Ă— 10-3-2.1 Ă— 10-3)

1985

(1980-1989)

   

Relaxed

1.8 Ă— 10-3

(1.4 Ă— 10-3-2.3 Ă— 10-3)

1986

(1981-1990)

  1. Estimates of the mean evolutionary rate (μ, substitutions site-1 year-1) and median time of the most recent common ancestor (Tmrca, year) of the HIV-1 CRF12_BF and CRF38_BF epidemics (95% HPD intervals in parentheses). The results reported are the combined estimates of two independent runs. a Informative prior distribution of μ (1.5 Ă— 10-3-2.5 Ă— 10-3) for the CRF38_BF pol data set was selected from: HuĂ© et al. [38], Salemi et al.[39], Bello et al.[40], and Passaes et al. [41].
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Retrovirology

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