Phylogenetic tree of lentiviral integrase core domains. Sequences adopted: human immunodeficiency virus type-1 (HIV-1) [PDB: 1BL3C]; human immunodeficiency virus type-2 (HIV-2) [PDB: 3F9K]; simian immunodeficiency virus, host: macaque (SIVmac251) [PDB: 1C6VC]; simian immunodeficiency virus, host: chimpanzee (Pan troglodytes) (SIVcpz) [accession: AAF18575]; simian immunodeficiency virus, host: gorilla (Gorilla gorilla) (SIVgor) [accession: ACM63211]; simian immunodeficiency virus, host: African green nonhuman primate (Chlorocebus sp.) (SIVagm) [accession: CAA30658]; simian immunodeficiency virus, host: mandrill (Mandrillus sphinx) (SIVmnd) [accession: AAB49569]; simian immunodeficiency virus, host: Cercopithecus lhoesti (SIVlhoest) [accession: AAF07333]; simian immunodeficiency virus, host: Skyes' nonhuman primate (Cercopithecus albogularis) (SIVsyk) [accession: AAS97874]; simian immunodeficiency virus, host: Colobus nonhuman primate (Colobus guereza) (SIVcol) [accession: AAK01033]; prosimian immunodeficiency virus, host: Microcebus murinus (pSIV) [see: additional material in Ref. ]; feline immunodeficiency virus, host: domestic cat (Felis sylvestris) (FIV-Pet) [accession: AAB59937]; lion lentivirus, host: lion (Panthera leo) [accession: ABX25835]; puma lentivirus, host: mountain lion (Puma concolor) [accession: AAA67168]; caprine arthritis-encephalitis virus (CAEV), host: Capra hircus [accession: NP_040939]; visna lentivirus, host: sheep (Ovis aries) [PDB: 3HPG_A]; equine infectious anemia virus (EIAV) host: horse (Equus caballus) [accession: NP_056902]; bovine immunodeficiency virus (BIV) host: wild banteng (Bos javanicus) [accession: Q82851]. Relationships between proteins were reconstructed using Phylogeny.fr. Approximate likelihood ratios > 70% are shown. This tree is not intended to reconstruct the phylogeny of primate lentiviruses, but rather to highlight the degree of similarity of the IN CCDs derived from different viruses. The similarities shown are in line with previous phylogenetic analyses based on DNA sequences corresponding to other portions of the lentiviral genome .