Figure 5

Correlation between systemic IL-22 and plasmatic CRP, LPS and IL-10 levels. (A) Systemic LPS levels were evaluated by the LAL assay, in plasma collected from HIV-1C-infected patients (n = 85) harboring either R/H (filled diamond) or S/L (open circle) growth phenotype viruses, or in 10 HIV-uninfected healthy controls (filled triangle). The mean plasmatic LPS values (pg/ml) are compared in the figure for R/H and S/L viral phenotype groups. Extreme outlier data points are not depicted for better visualization of results, but included into all calculations. *** = statistical difference of the medians, p < 0.001. (B) Correlation between plasma LPS (pg/ml) and plasma IL-22 levels (pg/ml). (C) Correlation between plasma IL-10 (pg/ml) and plasma IL-22 levels (pg/ml). (D) Correlation between plasma CRP (pg/ml) and plasma IL-22 levels (pg/ml) in our study sample (n = 85). In all panels, r = Spearman correlation coefficient; p-value (two tailed);p-values of the correlation coefficient of less than .05 were considered significant. The mean values of the measurements obtained from two independent experiments are shown.