Anti-tetherin activities in Vpu-expressing primate lentiviruses

Retrovirology

Table 1 Anti-tetherin factors in primate lentiviruses (PLV)

PLV lineages	Vpu?	Anti-tetherin factors previously reported	Proteins analyzed in this study
SIVcpz/HIV-1[23, 24, 44]	+	HIV-1 Vpu[2, 3]	HIV-1 NL4-3 Vpu
			SIVcpz GAB1 Vpu
			SIVcpz ANT Vpu
			SIVcpz MT145 Env/Vpu
			SIVcpz TAN3 Env/Vpu
			SIVcpz MB897 Env/Vpu, Nef
			SIVcpz EK505 Env/Vpu, Nef
SIVsm/mac/HIV-2[45, 46]	-	SIVsm Nef[9, 10]
		SIVmac239 Nef[9, 10]	SIVmac239 Nef
		HIV-2 ROD10 Env[7–9, 50]	HIV-2 ROD10 Env
SIVagm[47]	-	SIVsab Nef[10]
		SIVtan Nef[10, 11]
		SIVtan Env[11]
SIVsyk[48]	+¹	SIVmus Vpu² [11]	SIVmus 01CM2500 Vpu
			SIVmon 99CMCML1 Vpu
			SIVgsn 99CM71 Vpu
			SIVden Vpu
SIVl'hoest[49]	-	N/D
SIVcol[21]	-	N/D

¹ Vpu present only in SIVmus/mon/gsn sub-lineage and SIVden
² Activity reported for calculated ancestral sequence derived from four SIVmus Vpu sequences

ISSN: 1742-4690