Figure 3
From: Disease-associated XMRV sequences are consistent with laboratory contamination
Enumeration of nucleotide substitutions per site between the cell-line and patient-derived XMRV sequences . The pairwise genetic distance among pol and env sequences derived from 22Rv1 cells (white boxes) is significantly higher than among patient-associated sequences (grey boxes) (Wilcoxon rank sum test: p = 0.005 and p < 0.001 respectively). There is no significant difference in variation in the gag region. The top end of the y-axis was truncated to accommodate outliers in the gag 22Rv1 category. Outliers are due to APOBEC hypermutation.