Skip to main content

Advertisement

Volume 6 Supplement 2

Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts

Automated HTS/HCS for antivirals using visual HIV full replication assays

Retrovirologyvolume 6, Article number: P82 (2009) | Download Citation

There are currently 25 drugs belonging to 6 different inhibitor classes approved for the treatment of human immunodeficiency virus (HIV) infection. However, new anti-HIV agents and treatment strategies are still needed to confront the emergence of drug resistance and various adverse effects associated with long-term use of antiretroviral therapy and the inability to cure infected individuals. We developed visual, HIV full replication assays and implemented them in high-throughput compound (n = 200.000) and genome-wide siRNA screens, which allowed the identification of a few thousand novel small molecules with potent anti-retroviral activity and a few hundred host factors required for HIV infection, respectively. The identified compounds and host factors are opening unexplored avenues to novel antiviral drug and target discovery and validation, and should feed the drug development pipeline in the near future.

Author information

Affiliations

  1. Biology of Intracellular Pathogens Unit, Institut Pasteur Korea, Sampyeong-dong 696, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

    • Jean-Philippe Carralot
    •  & Priscille Brodin

  2. Screening Technology & Pharmacology Unit, Institut Pasteur Korea, Sampyeong-dong 696, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

    • Mi-Ri Kim
    • , Changbok Lee
    • , Hyunrim Oh
    • , Jonathan Cechetto
    •  & Thierry Christophe

  3. Cell Biology of Retroviruses Unit, Institut Pasteur Korea, Sampyeong-dong 696, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

    • Philippe Kieffer-Kwon
    • , Sandra Corre
    • , Annette Boese
    •  & Peter Sommer

  4. Drug Biology Unit, Institut Pasteur Korea, Sampyeong-dong 696, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

    • Hwa Pyung Kim
    •  & Sungjun Han

  5. Medicinal Chemistry Unit, Institut Pasteur Korea, Sampyeong-dong 696, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

    • Junwon Kim
    •  & Zaesung No

  6. Image Mining Unit, Institut Pasteur Korea, Sampyeong-dong 696, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

    • Boris Lenseigne
    • , Denis Fenistein
    •  & Thierry Dorval

Authors

  1. Search for Jean-Philippe Carralot in:

  2. Search for Mi-Ri Kim in:

  3. Search for Philippe Kieffer-Kwon in:

  4. Search for Sandra Corre in:

  5. Search for Hwa Pyung Kim in:

  6. Search for Junwon Kim in:

  7. Search for Boris Lenseigne in:

  8. Search for Changbok Lee in:

  9. Search for Denis Fenistein in:

  10. Search for Thierry Dorval in:

  11. Search for Hyunrim Oh in:

  12. Search for Sungjun Han in:

  13. Search for Zaesung No in:

  14. Search for Priscille Brodin in:

  15. Search for Jonathan Cechetto in:

  16. Search for Annette Boese in:

  17. Search for Thierry Christophe in:

  18. Search for Peter Sommer in:

Corresponding author

Correspondence to Peter Sommer.

Rights and permissions

Reprints and Permissions

About this article

Keywords

  • Human Immunodeficiency Virus
  • Infectious Disease
  • Treatment Strategy
  • Small Molecule
  • Drug Resistance

Retrovirology

ISSN: 1742-4690

Contact us