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Mother and fetal immunity to cytomegalovirus

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The pathogenesis of cytomegalovirus (CMV) transmission in utero remains poorly understood. Identification of the mechanisms involved and of biomarkers of transmission would help in the design and in the "proof of concept" evaluation of vaccine candidates. Primary CMV infection during pregnancy induces the differentiation of CD4 and CD8 T lymphocytes producing anti-viral cytokines. In contrast, proliferative responses of CD4 T cells are acquired slowly and are associated with a reduced risk of transmission. Defective CD4 T lymphocyte responses could allow the replication of CMV in organs involved in transmission and may limit the development of neutralising antibody responses. The development of severe symptoms and the prolonged viral excretion observed following CMV infection during fetal life may be related to defective immune responses. Mature CD8 T lymphocyte responses to CMV can be detected in infected newborns. In contrast, CMV induces the expansion and the differentiation of fetal CD4 T lymphocytes that are unable to produce anti-viral cytokines or proliferate in response to viral antigens. Our current understanding of mother and fetal immunity to CMV suggests that the virus interferes with the acquisition of specific functions of CD4 T lymphocytes, particularly during the early phase of the infection. The different expression of this interference in mothers and fetuses may involve the immaturity of antigen-presenting cells.

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Correspondence to Arnaud Marchant.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marchant, A. Mother and fetal immunity to cytomegalovirus. Retrovirology 6, L3 (2009) doi:10.1186/1742-4690-6-S1-L3

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Keywords

  • Severe Symptom
  • Antibody Response
  • Current Understanding
  • Proliferative Response
  • Vaccine Candidate