Figure 1

Clinical and virological profiles of experimentally infected horse #9807. Horse #9807 was experimentally infected with EIAV_PA by intravenous inoculation with 5 ml of plasma from the reference Pennsylvania field isolate inapparent carrier. Rectal temperatures (red line, right Y axis) and platelet counts (blue dashed line, 1^st left Y axis) were followed daily for approximately 550 days (X-axis). Quantitation of the virus load (green diamond, 2^nd left Y axis) was performed on viral RNA extracted from plasma at periodic time points during throughout the initial infection, fever episodes and asymptomatic stages. Febrile episodes were defined by a rectal temperature above 39°C in conjunction with a reduction in the number of platelets below 100,000/μl of whole blood and other clinical signs of EIA disease. The acute phase of disease (74DPI) from which viral populations were sampled is indicated (pink arrow).