Figure 8

Scheme for inhibition of HIV-1 infection by CPX and DEF. The model integrates results presented in this paper for the early phase of drug action with later events leading to apoptosis ([11] Hanauske-Abel et al., in preparation). In phase I the drugs cause a reduction in the expression of HIV proteins, some of which are necessary to prevent apoptosis of HIV infected cells. Apoptosis of infected cells takes place during phase II in the presence of the drugs.