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Table 1 Replication of SIV isolates derived from macaques infected with SIV alone or coinfected with SIV and HHV-6A in primary human T cells and coreceptor-transfected Ghost cell lines.

From: Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A

Isolates

Primary cells

Ghost cells expressing:

 

Normal PBMC

Δ32+/+ CD4+

BONZO

CX3CR1

CCR2

CCR3

CCR4

CCR6

CCR8

CXCR4

301

+

-

+

+

-

-

+

-

-

-

303

+

++

+

+

-

+

+

-

-

-

307

++

-

++

++

++

++

++

-

-

-

313

+

-

-

+

-

-

+

+

-

-

315

+

-

+

-

+

-

-

-

+

-

316

+

-

-

+

+

-

++

-

-

-

317

+

-

-

++

+

+

+

-

+

-

BaL

+++

n.d

-

-

-

-

+

-

+

-

LAV

+++

n.d

+

-

-

+

-

++

+++

+++

  1. The reference HIV-1 isolates BaL (R5) and LAV (X4) were tested in parallel as controls.
  2. - = no replication; + = weak replication; ++/+++ = strong replication; n.d = not determined.