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Figure 3 | Retrovirology

Figure 3

From: Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A

Figure 3

Cytokine secretion profiles in human lymphoid tissue infected with SIV isolates obtained from singly-infected and HHV-6A-coinfected macaques. Blocks of human lymphoid tissue were infected with SIV isolates. The concentrations of IL-2 (A), IFN-γ (B), IL-12 (C), and SDF-1β (D) were measured in conditioned culture medium from 27 tissue blocks using a multiplex bead-based assay. The data indicate the mean (± SEM) concentrations of each cytokine accumulated in the culture medium over 12 days in experiments with tissues from 5 human lymphoid tissue donors. Black: SIV from singly-infected macaques (#301, 303, 307); dark grey: RANTES-resistant SIV isolated from HHV-6A-coinfected macaques (#313, 315); light grey: RANTES-inducible SIV isolated from HHV-6A-coinfected macaques (#316, 317).

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Retrovirology

ISSN: 1742-4690

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