Figure 2

Sensitivity of SIV isolates derived from singly-infected and HHV-6A-coinfected macaques to RANTES- and HHV-6A-mediated inhibition. Blocks of human lymphoid tissues were infected with SIV isolates or coinfected with HHV-6A. Tissues were cultured with or without exogenous RANTES (100 nM). The data indicate means (± SEM) of cumulative viral replication levels expressed as percent of the levels measured in untreated controls. As expected in this model system, the range of SIV replication in different donor tissues was extremely variable (range: 150–19,000 pg/ml of p27 antigen). * = Statistically significant difference from the control. A-C. SIV isolates derived from singly SIV-infected animals. A: #301 (2 ≤ n ≤ 4); B: #307 (2 ≤ n ≤ 6); C: #303 (4 ≤ n ≤ 12). D-G. SIV isolates derived from HHV-6A-coinfected animals. D: #313 (4 ≤ n ≤ 11); E: #315 (2 ≤ n ≤ 4); F: #316 (3 ≤ n ≤ 10); G: #317 (3 ≤ n ≤ 7).