Figure 3

CD4⁺ T cell depletion and viral replication of wt and Δ nef HIV-1 in selected cohorts. Experimental data analyzed in Fig. 2 were divided into two groups based on differences in p24 production established for wt and Δnef viruses. Experiments, in which p24 production between wt and Δnef HIV-1 differed significantly (p > 0.05) were grouped as "different replication" (A). Experiments without significant difference (p < 0.05) in p24 production were considered as "similar replication" (B). Shown are p24 production and CD4⁺ T cell depletion of all individual experiments (left panels). p-values indicate statistical significance by Mann-Whitney-U analysis. The middle panels are boxplot presentations of the data on the left with the indicated upper and lower quartile, median, maxima and minima. In the right panels, data are presented to identify wt and Δnef pairs analyzed in parallel.