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Table 1 Characteristics of HERV-W env loci identified in this study as transcribed in human PBMC

From: Analysis of transcribed human endogenous retrovirus W env loci clarifies the origin of multiple sclerosis-associated retrovirus envsequences

HERV-W env locus strand location of amplicon in genome 5' LTR 3' LTR processed pseudogene full-length Env ORF
5q11.2 - 56852791 56853425 absent Δ325–780 + -
6q21 + 106788519 106789159 Δ1–255 Δ327–780 + -
7q21.2 (ERVWE1) - 91936808 91937448 complete complete - + (538 aa)
14q21.3 - 44559628 44559996 absent Δ327–780 + -
15q21.3 - 53385554 53386189 Δ1–255 Δ327–780 + -
17q12 + 32765922 32766546 absent Δ327–780 + -
Xq22.3 - 106183197 106183837 absent Δ327–780 + -*
  1. The chromosomal location of transcriptionally active HERV-W env loci is indicated in the first column. Nucleotide positions of amplicons on the respective chromosomes (human genome sequence March 2006 assembly) are indicated. Structures of the 5' and 3' LTRs of transcribed HERV-W env loci are given with respect to the 780-bp HERV-W LTR consensus sequence (LTR17) obtained from Repbase[37]. Missing nucleotides (Δ) in the LTRs as compared to the consensus LTR sequence are indicated. All but one locus represent processed pseudogenes. Presence of full length ORFs for HERV-W Env proteins is given in the final column.
  2. * The Xq22.3 locus contains an ORF for a hypothetical N-terminally truncated 475 amino acid HERV-W Env protein.