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Figure 6 | Retrovirology

Figure 6

From: Identification of two distinct structural regions in a human porcine endogenous retrovirus receptor, HuPAR2, contributing to function for viral entry

Figure 6

HuPAR1 and HuPAR2 chimeras reveal that the C-terminal two-thirds of HuPAR2 is responsible for the increased functionality compared to HuPAR1. eGFP-tagged chimeras (gray oval) were constructed between HuPAR1 (solid black) and HuPAR2 (dashed black). PERV-A 14/220* infection levels were determined for SIRC cells stably expressing each of the chimeric constructs. For purposes of comparison, we arbitrarily set the function of HuPAR1eGFP to 100%. The results indicate that HuPAR2 residues 170–448 contain the sequences responsible for the increased function for PERV-A infection.

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Retrovirology

ISSN: 1742-4690

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