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Table 3 Susceptibility of ITM4 pseudoviruses isolated at different time points to neutralization by autologous plasma and by Mabs.

From: Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies

Neutralizing activity of Autologous follow up plasma samples (ID50)a Monoclonal Antibodies (IC50)b
  ITM4_2001 ITM4_2004 ITM4_2005 ITM4_2007.1 ITM4_2007.2 MAb 4E10 MAb 2F5 MAb 2G12 MAb b12
Pseudoviruses (PV)   
PV ITM4_01 540 1905 >4680 4650 4475 0.23 0.21 >25 >25
PV ITM4_04 118 194 255 219 216 11.5 19 >25 >25
PV ITM4_07.1 <25 <25 <25 111 33 17.4 >25 12.75 >25
PV ITM4_07.2 <25 <25 <25 67 33 >25 >25 >25 >25
  1. aPlasma dilution causing 50% reduction of relative light units compared to the virus control.
  2. b Antibody concentration (μg/ml) causing 50% reduction of relative light units compared to the virus control.