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Table 3 Susceptibility of ITM4 pseudoviruses isolated at different time points to neutralization by autologous plasma and by Mabs.

From: Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies

Neutralizing activity of

Autologous follow up plasma samples (ID50)a

Monoclonal Antibodies (IC50)b

 

ITM4_2001

ITM4_2004

ITM4_2005

ITM4_2007.1

ITM4_2007.2

MAb 4E10

MAb 2F5

MAb 2G12

MAb b12

Pseudoviruses (PV)

  

PV ITM4_01

540

1905

>4680

4650

4475

0.23

0.21

>25

>25

PV ITM4_04

118

194

255

219

216

11.5

19

>25

>25

PV ITM4_07.1

<25

<25

<25

111

33

17.4

>25

12.75

>25

PV ITM4_07.2

<25

<25

<25

67

33

>25

>25

>25

>25

  1. aPlasma dilution causing 50% reduction of relative light units compared to the virus control.
  2. b Antibody concentration (μg/ml) causing 50% reduction of relative light units compared to the virus control.
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Retrovirology

ISSN: 1742-4690

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