Figure 3

Characterization of Env-Ory1. (A) Schematic representation of the Env-Ory1-associated ERV with the LTRs and the splice sites for the sub-genomic env transcript indicated. (B) Schematic structure, hydrophobicity profile and primary sequence of the Env-Ory1 glycoprotein (deposited in GenBank [GenBank:GU196371]). The SU and TM subunits of the envelope protein are delineated, with a canonical furin cleavage site (RQKR; consensus: R/K-N-R/K-R) between the two subunits and the CWLC domain involved in SU-TM interaction indicated in red; the hydrophobic signal peptide and fusion peptide and the transmembrane domain are shaded in light gray, and the putative immunosuppressive domain (ISU) in dark gray.