Table 2 IC50 values for RAL, EVG and MK-2048 for subtype B and subtype C integrase in Mg2+-based enzymatic assays.
From: Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes
Strand Transfer IC50 | ||
|---|---|---|
Subtype Ba | Subtype Ca | |
RAL (μM) | 0.0047 (0.0013-0.0064) | 0.0037 (0.0011-0.0086) |
MK-2048 (μM) | 0.0047 (0.0021-0.010) | 0.0023 (0.001-0.007) |
EVG (μM) | 0.0017 (0.0009-0.0051) | 0.0011 (0.0002-0.021) |