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Mother-to-child transmission (MTCT) of persistent viral infections: pathogenesis and prevention

Several viral infections, including human immunodeficiency virus, hepatitis B and C viruses, and cytomegalovirus can be transferred from mothers to their infants; these viruses may establish persistent infections and are a significant source of child morbidity and mortality globally. The development of successful preventive antiviral or vaccine strategies is dependent upon better understanding of the infection process and transmitted viral strains, along with defining immune correlates of protection against infection or natural disease. Unique features of MTCT may be particularly helpful in understanding correlates of immune protection. Neonatal vaccination may not only prevent mother-to-child transmission but may also provide lifetime immunity. It is thus also important to define how best to elicit durable protective immune responses in infants.

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Correspondence to Katherine Luzuriaga.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Immune Response
  • Hepatitis
  • Human Immunodeficiency Virus
  • Infectious Disease
  • Cancer Research