The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

Table 2 Analysis of inhibition of pseudotype infection in the presence of anti-CD4 antibody.

	BS	Bv1v3	Bv1v2	Br (N283T)	Spl	SB	Spl (T283N)	DS17	DS17 (N283T)
Br	0.2363	0.8349	0.0032	0.3344	0.0005	0.0004	0.0027	<0.0001	<0.0001
BS		0.2286	0.0010	0.2638	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
Bv1v3			0.0021	0.5091	<0.0001	0.0001	0.0010	<0.0001	<0.0001
Bv1v2				0.0472	0.0212	0.1048	0.1863	0.0002	0.0001
Br(N283T)					0.0008	0.0013	0.0064	<0.0001	<0.0001
Spl						0.1783	0.1787	0.7203	0.8227
SB							0.8959	0.0055	0.0066
Spl(T283N)								0.0067	0.0023
DS17									0.1487

Significance (p) values were obtained with an F test; p values below 0.05 were considered significant (shown in bold) an indicate rejection of the null hypothesis of a single best fit curve for both data sets.

ISSN: 1742-4690