Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors

Retrovirology

Table 2 Integrase positions at which different subtypes have different consensus residues

Subtype	No.	14	17	21	25	31	39	50	72	84	100	101	112	113	119	124	125	134
		K⁹⁴	S⁷⁶	A⁹⁵	D⁹⁶	V⁷⁷	S⁹¹	M⁸³	I⁵¹	I⁹⁸	F¹⁰⁰	L⁵⁶	T⁸⁷	I⁹⁰	S⁶⁹	T⁵⁴	T⁶⁹	G⁹⁸
A	160	R⁶⁴				I⁷⁷			V⁸⁹				V⁹²	V⁷⁵		A⁷⁸	A⁹⁶	N⁵⁷
AE	132	R⁹⁶		T⁸⁶		I⁸⁰	N⁷⁸		V⁹³				V⁹⁸			A⁹⁵	A⁹⁸	N⁹²
AG	93	R⁸⁹				I⁷²						I⁸³	V⁹¹			A⁹⁶	A⁹⁶	N⁸¹
C	432				E⁸¹	I⁷⁶		I⁵⁸			Y⁷²	I⁹⁵	V⁹²			A⁷⁰	A⁹²
D	82		N⁷⁰					L⁵⁹	V⁸²				V⁸⁴	V⁸⁹		A⁸²	A⁷⁸
F	57		N⁸¹						V⁷⁰	L⁸¹		I⁸⁶			T⁴⁶	A⁷⁰	A⁷⁰
															P⁴⁰
G	35	R⁸⁹				I⁶⁰						I⁸⁶	V⁷⁵			A⁷¹	A⁸⁶	N⁷¹
Subtype	No.	135	136	167	201	205	206	211	218	227	234	255	256	265	269	278	283
		I ⁹³	K ⁹⁷	D ⁹⁸	V ⁶²	A ⁹⁹	T ⁸⁶	K ⁸⁹	T ⁹²	Y ⁹⁵	L ⁸⁷	S ⁹⁷	D ⁷⁹	A ⁷⁸	R ⁹⁹	D ⁹⁸	S ⁸³
A	160		Q⁸⁶	E⁸¹	I⁹⁸						I⁷⁰						G⁷³
AE	132	V⁹²	R⁶⁹	E⁹³	I⁹⁸						I⁹⁶						G⁹⁶
AG	93	V⁷⁸	T⁸²		I⁹⁹		S⁹²				I⁹⁸						G⁸⁴
C	432		Q⁸⁹		I⁹⁸				I⁶⁴		I⁹⁸			V⁵⁵	K⁵⁷	A⁹⁴	G⁸⁷
D	82				I⁹⁸						I⁹⁴		E⁵⁷
F	57		Q⁸⁹		I⁹⁸	S⁶⁵		R⁵⁶	I⁷²		V⁹¹		E⁹⁶				G⁹¹
G	35		T⁹⁷		I⁹⁷		S⁹⁴			F⁵⁷	I⁹¹	N⁹⁴	E¹⁰⁰				G⁹⁴

Abbreviations: No. – number of sequences. The header shows the amino acid consensus for subtype B isolates. The individual rows indicate the amino acid positions at which specific subtypes have a consensus amino acid different from subtype B. The superscript indicates the proportion of isolates of that row's subtype which have the consensus amino acid for that subtype. Empty cells indicate that the subtype has the same consensus amino acid as the consensus for subtype B.

ISSN: 1742-4690