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Figure 4 | Retrovirology

Figure 4

From: HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4

Figure 4

LFA-1 independent cell-to-cell HIV transmission. Panel A depicts the expression of the indicated adhesion molecules on the surface of the 293T cell line. The percentage of positive cells is indicated in each histogram. Control histogram corresponds to background of staining. Panel B shows HIV transfer from 293T cells, transfected to produce HIV particles, to target CD4 T cells in the absence (light bars) or presence (grey bars) of NL4-3 Env expression. The effect on the addition of blocking antibodies against CD4 (Leu3a) and the gp41 inhibitory peptide C34 was also tested. Data (Mean ± SD) were obtained using cells from 3 different donors. Asterisk indicates a significant inhibition in HIV transmission in the presence of Leu3a within NL4-3 Env transfected 293T cells.

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Retrovirology

ISSN: 1742-4690

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