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Figure 3 | Retrovirology

Figure 3

From: HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4

Figure 3

The role of adhesion molecules on T cell-to-T cell HIV transmission. Blocking antibodies against the indicated cell surface molecules were used to inhibit the transfer of HIV particles after 2 h of coculture of primary CD4 T cells with uninfected MOLT (white bars), MOLT NL4-3 (grey bars) or MOLT BaL cells (dark bars). Concentrations were 10 μg/mL for all mAbs against cell surface molecules, except for Leu3a (5 μg/mL) and C34 (1 μg/mL). Data are Mean ± SD of 3 independent experiments employing cells of 3 different donors. Asterisks indicate a significant inhibition in HIV transmission in the presence of Leu3a.

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Retrovirology

ISSN: 1742-4690

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