Figure 2

Gp120 V2, V3 and V4 loop region amino acid sequences of chronic and end-stage R5 sequences. Each sequence depicts the consensus V2 (a), V3 (b) and V4 (c) loop sequences of four clones obtained from chronic asymptomatic (AS) and end-stage AIDS R5 isolates. Upper case letters illustrate amino acids present in all analyzed clones, i.e homogenous sites, lower case letters represent dominating amino acids in polymorphic sites. Bold letters show potential N-linked glycosylation sites (PNGS), blue shaded sites display homogenous PNGS and yellow shaded sites represent polymorphic PNGS. The arrows point out the V2 aa160 and the V4 aa406 positions.