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Table 1 Selectivity indices of aqueous Lamiaceae extracts in different HIV-1 infection models

From: Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density

Extract Cells IC50 (%)a CC50 (%)b Selectivity Indexc
Lemon balm SupT1 0.020 ± 0.012 0.38 ± 0.086 103 ± 66 (6)
  C8166 0.033 ± 0.020 > 1 > 63 ± 19 (4)
  C8166Entry 0.004 ± 0.002 > 1 > 1834 ± 930 (4)
  HLAC 0.054 ± 0.016 9.433 ± 0.463 210 ± 42 (3)d
Peppermint SupT1 0.190 ± 0.124 1.700 ± 0.497 71 ± 29 (6)
  C8166 0.026 ± 0.016 > 1 > 191 ± 87 (2)
  C8166Entry 0.005 ± 0.001 > 1 > 208 ± 40 (3)
  HLAC 0.666 ± 0.159 > 10 > 19 ± 6 (3)d
Sage SupT1 0.099 ± 0.066 1.742 ± 0.526 73 ± 28 (4)
  C8166 0.016 ± 0.005 > 1 > 82 ± 20 (4)
  C8166Entry 0.009 ± 0.004 > 1 > 198 ± 70 (3)
  HLAC 1.157 ± 0.672 > 10 > 22 ± 9 (3)d
  1. aInhibitory concentration 50, derived from experiments performed as shown in Figs. 1, 2A, 2B, 3A, 4B.
  2. bCytotoxic concentration 50, derived from experiments performed as shown in Figs. 1, 2A, 2B, 4C.
  3. cSelectivity indices (SI) determined by dividing the CC50 by the corresponding IC50 value from each individual experiment (and not the arithmetic means of CC50 and IC50 values shown in this table). IC50, CC50 and SI values shown represent the arithmetic mean SEM of (n) experiments.
  4. dShown is the SI for 3 out of 4 independent experiments. CC50 values in the 4th experiment were: Lemon balm CC50 > 1, sage and peppermint CC50 > 3.