Figure 3

Mutational spectra of subtype B patient-derived hypermutant HIV-1 protease sequences. All available subtype B protease sequences in the Los Alamos Database are included, excluding experimentally generated hypermutants. When multiple identical hypermutant sequences were cataloged for a given individual, a single representative is included. Mutations occurring at recognized protease inhibitor resistance positions are listed, based on Stanford HIV Drug Resistance Database conventions [51]. Class IV mutations are listed separately, and typically need to be coupled with other mutations to contribute to resistance. The right panel displays all mutations in each sequence with respect to the subtype B protease consensus sequence (generated using Hypermut [40]); red = GG -> AG (APOBEC3G pattern), cyan = GA -> AA (APOBEC3F pattern), green = GC -> AC, magenta = GT -> AT, black = all other mutations, yellow = deletion.