Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy

Table 3 Antigens discriminating between sustained and transient responders

Part A Antigens with significantly higher expression in SR compared to TR
Antigen	Baseline	TimePoint2	TimePoint3	TimePoint4	P value^a
CD11aSR^b	153 ± 28.1	152 ± 19.2	141 ± 25	157 ± 24.4	0.002
CD11aTR^c	130 ± 17.2	123 ± 17	124 ± 14.7	136 ± 9.6
CD29SR	145 ± 25.5	151 ± 14.3	147 ± 20.3	160 ± 23.1	0.001
CD29TR	120 ± 35.5	113 ± 10.5	129 ± 12.8	129 ± 16.2
CD38SR	119 ± 32.4	123 ± 13.7	131 ± 21.3	138 ± 19	0.045
CD38TR	105 ± 19.3	106 ± 28.4	109 ± 16.4	116 ± 20.1
CD45ROSR	107 ± 38.8	107 ± 17.9	105 ± 24.2	108 ± 19.2	0.003
CD45ROTR	72 ± 18.7	75 ± 17.5	64 ± 27.1	73 ± 30.5
CD52SR	127 ± 40.5	136 ± 15.9	136 ± 22.5	139 ± 10.9	0.048
CD52TR	112 ± 25.1	111 ± 19.6	114 ± 21.3	118 ± 19.3
Part B Antigens with significantly lower expression in SR compared to TR
Antigen	Baseline	TimePoint2	TimePoint3	TimePoint4	P value^a
CD56SR^b	0	17	17	17	0.047
CD56TR^c	17	33	33	83
CD57SR	33	50	17	50	0.022
CD57TR	83	67	83	83
CD62ESR	33	67	50	83	0.012
CD62ETR	83	83	100	100
CD64SR	67	83	83	67	0.012
CD64TR	100	100	83	100
CD33SR	17	17	50	50	< 0.001
CD33TR	100	100	83	83

Part A: Data presented are dot intensities, shown by mean ± standard deviation.
Part B: Data are presented as the percentage of patient samples showing detectable expression level of the corresponding antigens in each patient group since some samples had below detection expression levels for some antigens. The cut off value of 10 was used to identify detectable expression levels.
a Level of significance of the group parameter in a repeated measure mixed model analysis of variance was used to assess the difference in values between groups.
b SR: sustained responder group.
c TR: transient responder group.

ISSN: 1742-4690