Table 2 Turnover characteristics of HIV-1 RNA+ PBMC during cART
Cell numbersa | Decaying cell fraction | ||||
|---|---|---|---|---|---|
Class | Patient | Baseline (N0) | Plateau on cART (NP) | (1-NP/N0) | T1/2 (days)b |
ILow | 103 | 470 | 39 | 91.7% | 0.7 |
104 | 661 | 11 | 98.3% | 3.8 | |
110 | 582 | 29 | 95.0% | 2.5 | |
111 | 164 | 14 | 91.5% | 2.5 | |
112 | 89 | 11 | 87.6% | 6.3 | |
AllC: | 393 ± 114 | 21 ± 5.6 | 93 ± 1.8% | 3.2 ± 0.9 | |
IIMedium | 103 | 36 | 15 | 58.4% | 4.6 |
104 | 125 | 2.3 | 98.2% | 4.3 | |
110 | 122 | 8.2 | 93.3% | 6.3 | |
111 | 33 | 0.1 | 99.7% | 2.4 | |
112 | 68 | 1.3 | 98.1% | 3.2 | |
AllC: | 76 ± 20 | 5.4 ± 2.8 | 90 ± 7.9% | 4.1 ± 0.7 | |
IIHigh | 103 | 14 | ≤ 0.01 | ≥ 99% | 8.2 |
104 | 39 | ≤ 0.01 | ≥ 99% | 2.5 | |
110 | 4.9 | ≤ 0.01 | ≥ 99% | 13 | |
111 | 1.1 | ≤ 0.01 | ≥ 99% | 1.1 | |
112 | 18 | ≤ 0.01 | ≥ 99% | 2.3 | |
AllC: | 15 ± 6.6 | ≤ 0.01 | ≥ 99% | 5.4 ± 2.3 | |
IIIExtra | 103 | 25 | ≤ 0.01 | ≥ 99% | 3.8 |
104 | 25 | ≤ 0.01 | ≥ 99% | 1.7 | |
110 | 11 | ≤ 0.01 | ≥ 99% | 0.7D | |
111 | 1.7 | ≤ 0.01 | ≥ 99% | 0.7D | |
112 | 0.9 | ≤ 0.01 | ≥ 99% | 0.7D | |
AllC: | 13 ± 5.3 | ≤ 0.01 | ≥ 99% | 1.5 ± 0.6 | |
Total HIV+ (HIV-1 DNA) | 103 | 1808 | 326 | 82% | 22 |
104 | 4030 | 370 | 91% | 4.0 | |
110 | 8533 | 2488 | 71% | 174 | |
111 | 5965 | 938 | 84% | 17 | |
112 | 10094 | 4853 | 52% | 1.1 | |
AllC: | 6086 ± 14939 | 1795 ± 859 | 76 ± 6.8 | 44 ± 32 | |