MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes

Table 1 Genes with predicted simultaneous seed matches for miR-21, miR-24, miR-146a and miR-155.

Gene	Seed matches for miR				Seed matches in other databases	Gene ontology (GO) terms for biological processes
	21	24	146a	155
SH3TC2	1	2	3	3	155¹	signal transduction
ITGB3	3	2	3	1	-	cell adhesion
MMP16	2	1	2	3	24^1,2, 146a¹, 155³	-
PURB	2	2	2	2	21^1,2, 24^1,2	regulation of myeloid cell differentiation
FAM130A1	1	1	3	2	155³	positive regulation of transcription
SMAD5	2	1	3	1	-	signal transduction (TGF-β)
ONECUT2	2	2	1	2	146a³	organ morphogenesis
DCX	1	2	1	2	-	CNS development
EIF2C4	2	1	2	1	-	chromatin silencing
CBFA2T2	1	2	1	2	-	negative regulation of transcription
JHDM1D	3	1	1	1	21³	-
SLC12A6	1	1	1	2	24^1,2,3, 155³	cell volume homeostasis
ZNF532	1	1	2	1	146a¹	-
TP53INP1	2	1	1	1	24^1,2, 155^1,2,3	-
KIAA1128	2	1	1	1	-	-
CLCN5	2	2	1	1	24¹	excretion
FLJ25778	1	1	2	1	-	-
CREBL2	1	1	1	2	21^1,2, 24^1,2, 146a³	signal transduction transcription
RFXDC2	1	1	1	2	146a^1,3	-
YOD1	1	1	1	2	21¹, 24¹	amino acid metabolic process
VGLL3	2	1	2	1	24³	-
PPM1D	1	1	1	2	-	negative regulation of cell proliferation
CYBB	1	2	1	2	-	innate immune response, inflammatory resp
RP11-93B10.1	1	1	1	1	24³, 146a^1,2, 155¹	-
COL19A1	1	1	1	1	155³	-
LOC348120	1	1	1	1	-	-
AFF1	1	1	1	1	-	transcription
RDX	1	1	1	1	-	-
RIT1	1	1	1	1	21¹, 24¹, 155	signal transduction
USP31	1	1	1	1	-	-
ARHGEF1	1	1	1	1	21³	cell proliferation
SERTAD2	1	1	1	1	155¹	negative regulation of cell growth

In silico analysis (microRNA.org) of genes carrying at least one binding site for each of the four microRNAs. Results were compared to those obtained from other databases (TargetScan, PicTar, mirDB) and hits listed in column "Seed matches in other databases".
¹TargetScan, ²PicTar, ³mirDB

ISSN: 1742-4690