Figure 7

Schematic comparison of SIV with full length and truncated Env. Replication of SIV with full length Env (A) or with truncated Env (B) in permissive (monkey PBMC) cells (left diagrams) and non-permissive cells (brain cells, macrophages) (right diagrams). Schematic depiction of the trafficking of SIV in cells: Gray dashed arrows depicted raft-associated pathway; black dashed arrow depicts alternative pathway; black arrows depicted sites of transcription. SIV with truncated Env can overcome a restriction in an early replication step by high multiplicity of infection and productively infect cells.