Figure 6
From: The contribution of peroxynitrite generation in HIV replication in human primary macrophages
Removal of free radicals by MnTBAP is involved in macrophages HIV replication. Infectivity of virus particles produced by HIV-1-infected macrophages was evaluated on macrophages obtained from a different seronegative donor exposed to serial dilution of supernatants from MnTBAP treated or not-treated HIV-1-infected macrophages. The TCID50/ml was calculated according to Reed and Muench method. MnTBAP reduces TCID50 about a log both in acutelly (Panel A) as in chronically (Panel B) HIV-1-infected macrophages compared to infected and non treated macrophages.