Table 5 Predicted CTL epitopes in HIV-1 gag and env-V3 (according to the patients HLA type) and their evolution
From: HIV-1 sequence evolution in vivo after superinfection with three viral strains
Protein, position | CTL epitope | HLA-I type | Subtype B1 2001 | Subtype B2 2002 | Subtype AE 2003 |
|---|---|---|---|---|---|
Gag p17, 18–28 | KIRLRPGGK or RLRPGGKKK | A3 | KIRLRPGGKKR* K→R (42%) in 2005 | KIRLRPGGKKS S→R (100%) in 2005 | KIRLRPGGKKQ, no changes over time |
Gag p17, 74–82 | ELRSLYNTV | B8 | ELKSLYNTV, 50% V→I in 2005 | ELKSLFNTV, 67% F→Y in 2005 | ELKSLYNTV, no changes over time |
Gag p17, 93–101 | EIKDTKEAL | B8 | EVKDTKEAL, 83% V→I in 2005 | DVKDTKEAL, no changes over time | EILDTKEAL, no changes over time |
Gag p24, 8–21 | GQMVHQAISPRTLN | A3- supertype Cw3 | GQMVHQPISPRTLN, no changes over time | GQMVHQPISPRTLN, no changes over time | GQMVHQPVSPRTLN, no changes over time |
Gag p24, 41–60 | SALSEGATPQDLNTMLNTVG | unknown | SALSEGATPQDLNTMLNTVG 92% S→T in 2005 | SALSEGATPQDLNTMLNTVG 96% S→T in 2005 | SALSEGATPQDLNMMLNIVG, no changes over time |
Env-V3, 296–305 | CTRPNNNTRK | A3 | CTRPSNNTRK, no changes over time | CTRPSNNTRK, no changes over time | CTRPSNNTRT, no changes over time |
Env-V3, 308–322 | RIQRGPGRAFVTIGK | A3 | SIHIAPGRAFYATGE, no changes over time | SIHMGPGKAFFTTGE, no changes over time | SIHMGPGQVFYRTGD, no changes over time |