Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome

Table 1 Impact of various coding and non-coding compensatory mutations on SD2 fitness.

	Mutation	Location	Charge	Processing	Infectivity	RNA incorporation
CEMx174	A420G	DIS-SL	n/a	n/c	+++	+++
	E18G	NC	+	+++	+	+
	G31K	NC	+	+++	++	++
C8166	A420G	DIS-SL	n/a	n/c	+++	+++
	K197R	CA	n/c	n/c	++	+
	G49K	P6	+	+++	++	+

Legend: + = moderate recovery, +++ = near complete recovery, n/a = not applicable, n/c = no change

ISSN: 1742-4690