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Table 1 Impact of various coding and non-coding compensatory mutations on SD2 fitness.

From: Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome

  Mutation Location Charge Processing Infectivity RNA incorporation
CEMx174 A420G DIS-SL n/a n/c +++ +++
  E18G NC + +++ + +
  G31K NC + +++ ++ ++
C8166 A420G DIS-SL n/a n/c +++ +++
  K197R CA n/c n/c ++ +
  G49K P6 + +++ ++ +
  1. Legend: + = moderate recovery, +++ = near complete recovery, n/a = not applicable, n/c = no change
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Retrovirology

ISSN: 1742-4690

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