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Table 1 Subjects, longitudinal blood samples and corresponding laboratory studies.

From: Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

Subject Date infected Date of bloodsample CD4+ T-cellsa (cells/μl) Viral load b (RNA copies/ml) HIV-1 progression statusc No. Rev clones sequencedd
D36 12/1980. 5/1995 N/A 1400 SP 10
   1/1997 367 3200   10
   7/1999 N/A BD   10
   4/2001 476 BD   10
C18 8/1983 12/1993 809 N/A LTNP 10
C64 4/1983 8/1996 925 BD LTNP 10
   8/1997 805 BD   10
   4/1999 1026 BD   10
   5/2000 875 BD   10
C98 2/1982 10/1995 576 670 SP 10
   2/1997 629 770   10
   11/1999 646 690   10
   5/2001 527 760   10
  1. a; CD4+ T-cells were measured by flow cytometry.
  2. b; Plasma HIV-1 RNA was measured by COBAS Amplicor HIV-1 Monitor Version 1.0 (Roche Molecular Diagnostic Systems, Branchburg, N.J.) prior to July 1999 and Version 1.5 after July 1999. HIV-1 RNA levels < 400 copies/ml (Version 1) or < 50 copies/ml (Version 1.5) were considered below detection.
  3. c; The clinical status of the subjects has been described in detail previously [3, 4, 27].
  4. d; The consensus sequences of the 10 Rev clones sequenced from each time point are shown in Additional file 1.
  5. BD, below detection; N/A, not available; SP, slow progressor; LTNP, long-term nonprogressor.