Figure 1

Amino acid sequences of persistent and dominant SBBC rev alleles. The HIV-1 Rev amino acid sequences shown represent those derived from the dominant and persistent rev alleles harboured by SBBC subjects C18, C64, C98 and D36. They are the consensus sequences of multiple independent Rev clones that persisted over a 4- to 6-year period in C64, C98 and D36, or which were dominant in a single blood sample obtained from C18 [see Additional file 1]. Amino acid alignments are compared to Rev from HIV-1_NL4-3. Dots indicate residues identical to HIV-1_NL4-3 Rev, and dashes indicate gaps. Boxed residues indicate amino acid substitutions which discriminate C18 and C98 Revs from C64 and D36 Revs. NLS; nuclear localization signal, RBD; RNA binding domain, NES; nuclear export signal.