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Figure 2 | Retrovirology

Figure 2

From: Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

Figure 2

Effect of tenofovir therapy on mean viral RNA levels and CD4+ T lymphocyte counts. (A) Following tenofovir treatment (vertical dotted line), the average viremia (mean +/- SEM, calculated after log transformation) declined to approximately 1 log below pre-therapy baseline levels; note that the length of the SEM bars indicates larger variability of viremia after tenofovir therapy than before treatment (as shown in the individual graphs in figure 3). (B). The time course of CD4+CD3+ T lymphocyte counts in peripheral blood of the 12 animals is presented as absolute values (mean +/- SEM) along the left Y-axis; in addition, for each individual animal, the change in CD4+ T cell counts relative to its pre-infection value (time zero) was calculated, and the mean +/- SEM of these changes is presented along the right Y-axis. Both analyses gave (as expected) identical statistical conclusions.

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Retrovirology

ISSN: 1742-4690

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