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Figure 4 | Retrovirology

Figure 4

From: Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

Figure 4

Transmission electron microscopy analysis of mutant and wild-type virions as described previously [4]. (A) With the control virus, a dense core material was shown inside the envelope of immature virus (left panel) and mature virus with dense conical core structure (right panel). (B) Many particles produced by cells transfected with the E98A mutant had either virions with an immature structure or abnormal core morphology (left panel) and a very few detectable cones. Under higher magnification, the E98A virions were observed to be a heterogeneous population of particles (right panel) with varying size and conical core structures, where a number of virions with an electron-lucent centre and aberrant cores were detected (lower panel). (C) E187G virions with a characteristic dense conical core material. Bars, 100 nm. (D) Numerical (%) analysis of 372 wild type NL4-3 and 798 E98A virus particles with respective morphology.

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Retrovirology

ISSN: 1742-4690

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